Chronic Intoxication by Cadmium Experimentally Induced in Rabbits

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Abstract
The ultrastructural alterations caused in the kidney by chronic intoxication with cadmium salts have been studied in rabbits treated for periods of from 2 weeks to 7 months. Submicroscopic observations failed to demonstrate a visible localization of cadmium in the renal parenchyma. We observed variable regressive and degenerative patterns of the tubular epithelium which were more evident after 5 and 7 months of treatment. Severe glomerular amyloidosis was seen in animals treated for 2 and 7 months, while it was minor in rabbits treated for 4 and 5 months. The possible relationship between cadmium and enzyme systems controlling protein catabolism, and that between cadmium and amyloidosis have been discussed.

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