Effects of Antimetabolites of Nucleic Acid Components on the Growth of Diplodia natalensis

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Abstract
Purines, pyrimidines, folic acid, and antimetabolites of these compounds were tested for their effects on the growth of a pro-totrophic strain of the fungus, P. natalensis. Growth was severely inhibited by 8-azaguanine and the inhibition relieved by adenine and guanine. Thiouracil was the most potent antipyrimi-dine tested, and its effects were overcome by cytosine, thymine, uracil, or orotic acid. Aminopterin and amethopterin were both highly inhibitory antimetabolites of folic acid. Folic acid, adenine, guanine, thymine, and uracil reversed these inhibitions. The implications of some of these findings were discussed.