Cross-Linking of Collagen
- 11 May 1973
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 180 (4086) , 561-566
- https://doi.org/10.1126/science.180.4086.561
Abstract
The formation of collagen cross-links is attributable to the presence of two aldehyde-containing amino acids which react with other amino acids in collagen to generate difunctional, trifunctional, and tetrafunctional cross-links. A necessary prerequisite for the development of these cross-links is that the collagen molecules be assembled in the naturally occurring fibrous polymer. Once this condition is met, cross-linking occurs in a spontaneous, progressive fashion. The chemical structures of the cross-links dictate that very precise intermolecular alignments must occur in the collagen polymer. This seems to be a function of each specific collagen because the relative abundance of the different cross-links varies markedly, depending upon the tissue of origin of the collagen.Keywords
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