Phase I trials in paediatric oncology ? the European perspective
- 1 January 1996
- journal article
- Published by Springer Nature in Investigational New Drugs
- Vol. 14 (1) , 23-32
- https://doi.org/10.1007/bf00173679
Abstract
The current recommendations for Phase I trials should allow more confident interpretation of the toxicity and efficacy of new agents by providing a framework for multicentre and international co-operation. An overview of the aims and designs of Phase I trials is presented, along with a summary of current and recently published United Kingdom Childrens Cancer Study Group Phase I trials, and a discussion of some of the difficulties faced in the methodology and evaluation of Phase I studies in children.Keywords
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