Effects of Butyrophenone and Phenothiazine Derivatives on the Caudate Spindle

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Abstract
Effects of butyrophenone and phenothiazine derivatives on the caudate spindle were examined in gallamine-immobilized cats. Butyrophenone derivatives (haloperidol, trifluperidol and methylperidol; 0.5–8.0 mg/kg i.v.) inhibited the caudate spindle activity in a dose-related manner by 13.5–86.5%. Phenothiazine derivatives (chlorpromazine, perphenazine and trifluoperazine; 0.5–8.0 mg/kg i.v.) inhibited the caudate spindle activity only by 4.0–25.1%. The difference of central action between the two derivatives is discussed.

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