Contribution of Post-Secretory Mechanisms to the Observed Pattern of Histamine and 5-Hydroxytryptamine Secretion from Peritoneal Rat Mast Cells in Response to Compound 48/80
- 1 January 1989
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 90 (4) , 387-394
- https://doi.org/10.1159/000235059
Abstract
Compound 48/80 induces a greater percentage release of histamine than 5-HT from purified peritoneal rat mast cells such that the log-concentration effect curves diverge. Mast cells were shown to remove histamine and 5-HT applied exogenously, although uptake of 5-HT was in preference to that of histamine. At concentrations of clomipramine and fluoxetine that were shown to inhibit 5-HT uptake, the net percentage release of 5-HT increased in a corresponding manner. Likewise, pargyline and nialamide, which inhibit monoamine oxidase, potentiated the release of 5-HT, although they were without effect upon 5-HT uptake. Observed differences in the pattern of histamine and 5-HT secretion are proposed to be the result of post-secretory events involving amine reuptake and metabolism rather than a reflection of differential release mechanisms.This publication has 1 reference indexed in Scilit:
- Catabolism of Physiological Quantities of Histamine in VivoPhysiological Reviews, 1959