Effects of 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin (TCDD) on de novo fatty acid and cholesterol synthesis in the rat
- 1 September 1988
- Vol. 23 (9) , 904-906
- https://doi.org/10.1007/bf02536213
Abstract
The effects of 1, 5, 10 and 20 μg/kg dosages of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) upon de novo fatty acid and cholesterol synthesis in liver and adipose tissue were determined in pair-fed rats. The incorporation of tritium from3H2O into tissue lipids was measured. Hepatic and adipose fatty acid synthetic rates (μmoles acetyl units g−1 hr−1 in the control groups were 19.6±4 and 75.7±18.5, respectively, and the liver cholesterol synthetic rate was 2.9±0.5 TCDD (1 μg/kg) inhibited fatty acid synthesis in the liver and adipose tissue, by 44% and 41% respectively, and the liver cholesterol synthesis was inhibited by 37%. The extent of these inhibitions increased with increasing dosages of TCDD. The effect of TCDD on sterol synthesis in adipose tissue could not be determined, because the tritium incorporation into the sterol fraction in this tissue was not detectable.This publication has 25 references indexed in Scilit:
- Dose-response and time course of hypothyroxinemia and hypoinsulinemia and characterization of insulin hypersensitivity in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated ratsToxicology, 1987
- Effect of drugs, peptide hormones and lipogenic precursors on the relative incorporation of [3H]H2O and carbon into hepatic cholesterolFEBS Letters, 1985
- Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on lipid profiles in tissue of the Fischer ratChemico-Biological Interactions, 1978
- The comparative toxicity of chlorinated dibenzo-p-dioxins in mice and guinea pigsToxicology and Applied Pharmacology, 1978
- Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rhesus monkeys (Macaca mulatta) following a single oral doseToxicology and Applied Pharmacology, 1978
- Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-diozin for rhesus monkeys: Brief reportBulletin of Environmental Contamination and Toxicology, 1977
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD): Results of a 13-week oral toxicity study in ratsToxicology and Applied Pharmacology, 1976
- General biological effects of TCDD in laboratory animals.Environmental Health Perspectives, 1973
- The Toxicity of Polychlorinated Polycyclic Compounds and Related ChemicalsCRC Critical Reviews in Toxicology, 1973
- Effect of tetrachlorodibenzo-p-dioxin on growth rate and the synthesis of lipids and proteins in ratsBulletin of Environmental Contamination and Toxicology, 1972