Reagent control of cram-type selectivity in the mukaiyama aldol catalysed by supersilylating agents
- 1 January 1995
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 21,p. 2173-2174
- https://doi.org/10.1039/c39950002173
Abstract
In the addition of silyl enol ethers 8 to α-asymmetric aldehydes 1 and 2, catalysed by ‘supersilylating agents’ R3SiB(OTf)4, †; the level of Cram-type selectivity correlates with the steric bulk of the silyl group; use of the triisopropylsilyl enol ether 8d results in unprecedented levels of 1, 2-asymmetric induction.Keywords
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