Some Distinctive Biological Characteristics of Echo-10 Virus.

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Abstract
The susceptibility of primate and non-primate kidney tissue cultures to ECHO-10 virus was shown to be distinctive and unique as compared to other human enteroviruses. ECHO-10, unlike any other human enteric virus, multiplied and produced cytopathic changes in kidney tissue cultures derived from swine, cat, dog, guinea pig, and to some extent rabbit and calf. A similar host cell range was found for the group A ECMO (enteric cytopathogenic monkey orphan) viruses and the ECBO (enteric cytopathogenic bovine orphan) strain of moll. Virus titers obtained from the non-primate kidney cultures were essentially the same as those obtained in primate kidney cell tubes. In addition to its distinctive type of degeneration in fluid medium, ECHO-10 was the only one of the enterovirus group (poliovirus types 1-3, Coxsackie virus A-9, B 1-5, ECHO virus types 1-14) which caused readily recognizable destruction of patas and rhesus cells, but was unable to produce plaques under agar overlay. Capuchin monkey kidney cultures were found to be susceptible only to ECHO-10 among the enteroviruses tested.