A Facile Synthesis of Fragment D of Antibiotic, Nosiheptide
- 1 November 1995
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1995 (11) , 1423-1426
- https://doi.org/10.1055/s-1995-4117
Abstract
A facile synthesis of the N,O-diprotected fragment of D of Nosiheptide, 2-[(1’S,3’S)-1’-amino-3’-carboxy-3’-hydroxypropyl]thiazole-4-carboxylic acid, from (S)-2,2-dimethyl-1,3-dioxalane-4-acetaldehyde in 10 steps and 10.6% overall yield, is described.Keywords
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