THE EFFECTS OF VARIATIONS IN INSPIRATORY: EXPIRATORY RATIO ON CARDIORESPIRATORY FUNCTION DURING CONTROLLED VENTILATION IN NORMO-, HYPO- AND HYPERVOLAEMIC DOGS
Open Access
- 1 November 1970
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 42 (11) , 935-940
- https://doi.org/10.1093/bja/42.11.935
Abstract
Changes in cardiorespiratory function resulting from the use of three different inspiratory: expiratory ratios (1:2, 0.5:2.5, and 2:1) have been studied in normo-, hypo- and hypervolaemic dogs. Deadspace/tidal volume ratio increased slightly with the 0.5:2.5 ratio in all the states of blood volume but the changes were not statistically significant. There was a significant increase in arterial-alveolar Pco2 difference on the 0.5:2.5 ratio in the hypervolaemic state and there was a significant reduction in the Pco2 difference with the 2:1 ratio in the normovolaemic state. There was a significant reduction in arterial Po2 and a significant increase in venous admixture on the 0.5:2.5 ratio in the hypervolaemic state. Cardiac output was reduced after haemorrhage and increased after overtransfusion but there were no significant changes resulting from changes in the I: E ratio within each state of blood volume.Keywords
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