Effect of Side Chain in Macrocyclic Carriers on the Carrier-Mediated Transport of Amino Esters across Supported Liquid Membranes

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Abstract
The rate of transport of L-leucine and L-tryptophan methyl esters through supported liquid membranes containing dibenzo-18-crown-6 and its acyl derivatives was measured. The amino ester competed with the coexisting sodium ion in membrane transport. In the case of lipophilic amino ester such as tryptophan methyl ester, the flux of sodium ion decreased. For the C3 to C8 acyl derivatives, no appreciable difference in flux of the amino ester was observed, whereas that of sodium ion revealed a minimum at the C4 derivative. In a high concentration region of the C8 derivative, the flux of leucine methyl ester remained constant.