Ascorbic acid and aging in the rat. Uptake of ascorbic acid by skin and bone marrow, and its concentration in various organs

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Abstract
Parallel experiments to determine the uptake of ascorbic acid by the skin and bone marrow and for the determination of its concentration in the skin, liver, brain and kidney were undertaken in 2-, 10- and 50-week-old rats to evaluate the role of ascorbic acid at different ages of the animal. There was a general decrease with age of the concentration of ascorbic acid in various organs, including the liver. It is possible that there may be a decrease with age in the activities of the enzymes responsible for the synthesis of ascorbic acid in the liver.