THE METABOLISM OF DOGS WITH PERMANENT DIABETES PRODUCED BY ANTERIOR PITUITARY EXTRACT

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Abstract
The metabolism of dogs made permanently diabetic by a series of injs. of ant. pituitary extract has been correlated with the severity of the diabetes, (as indicated by the proportion of the available glucose of the ingested diet excreted in the urine). The fasting blood sugar of moderately or severely diabetic dogs varied widely. The conc. of serum fatty acids was greatly increased in untreated severely diabetic dogs; insulin therapy resulted in a marked decrease. In pituitary-diabetic dogs with a fasting urinary glucose and N excretion similar to that of totally depan-creatized dogs the feeding of fat was not associated with an increased excretion of glucose, N or ketone bodies, whereas the feeding of meat produced a glucose and N excretion greater than that available from the food and the ketone excretion was much greater than during periods of fasting or fat feeding. In a less severely diabetic dog meat feeding also produced a much greater ketonuria than that found during periods of fat feeding. The avg. O2 consumption of a moderately-severe pituitary-diabetic dog was 19% greater than that observed before the production of the diabetes; insulin treatment reduced O2 consumption about 20%. The avg. R.Q. of untreated diabetic dogs was 0.68, and glucose or meat produced little or no change in it.