Idiopathic Sexual Precocity in a Boy with Growth Hormone, Prolactin and Thyrotropin Deficiencies

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Abstract
A boy is described in whom growth hormone, prolactin and TSH deficiencies were associated with normal ACTH function and hypersecretion of FSH and LH, causing precocious puberty. Serum levels of FSH, LH and testosterone were appropriate for midpuberty, as were his levels during sleep and his response to stimulation with LH-RH. His FSH and LH concentrations were readily suppressed by administered fluoxymesterone. These findings suggested an underlying hypothalamic basis for the syndrome. However, the finding of low TSH and prolactin levels with no response to TRH or chlorpromazine stimulation suggested a primary defect of pituitary cells. At the present time the etiology of these apparent combined hypothalamic and pituitary defects remains obscure.

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