FUNCTIONAL HETEROGENEITY AMONG T-DERIVED LYMPHOCYTES OF MOUSE .6. MEMORY T CELLS STORED IN T2 SUBPOPULATION

  • 1 January 1976
    • journal article
    • research article
    • Vol. 117  (6) , 2131-2136
Abstract
Memory T [thymus-derived] cells were demonstrated in mice which were the precursors for cells causing sheep red blood cell-(SRBC) specific helper activity in the in vitro response of spleen cells to trinitrophenyl (TNP)-SRBC. These memory cells were distinguished from the effectors of helper activity generated during the primary response. The cells belonged to the T2 subpopulation of peripheral T cells on the basis of their rapid response to a challenge with SRBC, their long lifetime and their sensitivity to small in vivo doses of anti-thymocyte serum.