Antibody Affinity in Infants after Immunization with Conjugated Capsular Polysaccharide from Haemophilus influenzae Type b

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Abstract
The affinities of IgG antibodies to Haemophilus influenzae b capsular polysaccharide (polyribosyl ribitol phosphate [pRP]) elicited 1 month after immunization of47 infants 2->18 months of age with a PRP-outer membrane protein conjugate (PRP-OMP) were measured by ELISA. Thirty-four sera had affinities distributed normally about a logarithmic mean of 3.2 × 105 l/mol, but 13 samples had undetectable affinities 18 months of age (4.2 × 104 l/mol). Sera from children >18 months of age vaccinated with PRP conjugated to diphtheria toxoid had a median affinity of 6.1 × 104 l/mol, equivalent to that of the same age group vaccinated with PRP-OMP. Children vaccinated with PRP conjugate vaccines may produce antibodies ofvery low affinity, a finding that may have significance for protection from invasive disease.

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