Reactions of Trifluoroacetonitrile Oxide or -nitrilimines with β-Diketones and β-Keto Esters
- 1 August 1986
- journal article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 59 (8) , 2631-2632
- https://doi.org/10.1246/bcsj.59.2631
Abstract
N-Phenyl-C-(trifluoromethyI)nitrilimine cyclized with β-diketones or β-keto esters under alkaline conditions to give the corresponding 3-trifluoromethylpyrazoles with acyl or alkoxycarbonyl group at the 4-position of the ring, respectively. While trifluoroacetonitrile oxide with β-diketones provided the corresponding trifluoromethylisoxazoles, its reactions with β-keto esters gave 4-acyl-5-hydroxy-3-trifluoromethylisoxazoles as well as the expected isoxazoles without the regioselectivity.Keywords
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