Design, Synthesis, and Evaluation of Naphthalene-Sulfonamide Antagonists of Human CCR8
- 10 January 2007
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 50 (3) , 566-584
- https://doi.org/10.1021/jm061118e
Abstract
The design, synthesis, and structure−activity relationship development of naphthalene-derived human CCR8 antagonists is described. In vitro binding assay results of these investigations are reported, critical interactions of the antagonists with CCR8 are defined, and preliminary physicochemical and pharmacokinetic data for the naphthalene scaffold are presented.Keywords
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