Growth and fermentation model for alginate-entrapped Saccharomyces cerevisiae

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Abstract
A model of growth and fermentation for alginate-entrapped Saccharomyces cerevisiae is presented. The model is based on Peringer''s rate equations (Peringer, P.; et al. Biotechnol. Bioeng. Symp. 1973, 4, 27-42), developed for glucose-repressed cultures of suspended cells at varying dissolved oxygen concentrations, and was fitted to estimates of growth and fermentation rates for immobilized cells obtained through a combination of experimental measurements and reaction-diffusion analysis. Immobilized cell fermentation data with alginate beads in suspension compared well with simulations of reaction and diffusion in a similar system incorporating the proposed growth-fermentation model. In view of these findings, the model was further applied to the simulation of transient and steady-state operation of a packed-bed immobilized cell bioreactor. Results about the effect of operating parameters on bioreactor performance are presented, and implications regarding system design and operation for optimal overall performance are discussed.

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