Fibrous Cystic Mastopathy and Epitheliosis in the Opposite Breast of Mammary Carcinoma Patients

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Abstract
An autopsy study was made of opposite breasts obtained from 54 women aged from 29 to 84 years with a histologically confirmed mammary carcinoma. Fibrous cystic mastopathy – defined by fibrosis, duct ectasia, and acinus cysts – was found in 39 of the 54 opposite breasts examined (72%). Epitheliosis, which also occurs independently of mastopathy, was observed in 21 cases (39%). Three cases of the series under study showed epithelial proliferations qualitatively and quantitatively strikingly expressed in both the opposite breasts as well as in the comparatively reexamined cancer-bearing breasts. These marked epithelial proliferations can be regarded as the basis of the primary mammary carcinoma, or as a possible germ of a second primary carcinoma in the opposite breast.

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