Asymmetric cyclopropanation in protic media conducted by chiral bis(hydroxymethyl-dihydrooxazolyl)pyridine–ruthenium catalysts
- 14 December 2000
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 1,p. 59-60
- https://doi.org/10.1039/b008516m
Abstract
Cyclopropanation of styrene with diazoacetates, performed in aqueous/organic biphasic media or homogeneous alcoholic media in the combination of toluene by using chiral bis(hydroxymethyldihydrooxazolyl)pyridine–ruthenium catalyst, resulted in high enantiomeric excess up to 96–97% and trans∶cis stereoselectivity to 97∶3.Keywords
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