Prevention of experimental subarachnoid hemorrhage-induced intracranial arterial vasonecrosis with phosphodiesterase inhibitor phthalazinol (EG-626).
- 31 October 1979
- journal article
- research article
- Published by Wolters Kluwer Health in Stroke
- Vol. 10 (6) , 638-644
- https://doi.org/10.1161/01.str.10.6.638
Abstract
Experiments in monkeys have demonstrated that the chronic vasospasm and arterial injury reaction produced by subarachnoid blood injection can be prevented by treatment with the phosphodiesterase inhibitor phthalazinol. This protective effect, which is present even when the drug treatment is initiated after the subarachnoid blood injection, is presumed to occur because of the platelet inhibiting effect of phthalazinol.This publication has 4 references indexed in Scilit:
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- Platelet factors stimulate fibroblasts and smooth muscle cells quiescent in plasma serum to proliferate.The Journal of cell biology, 1976
- Personal ViewBMJ, 1974