Principles of Column Performance in Large Scale Gas Chromatography

Publisher Website
Google Scholar
Abstract
The loss of efficiency in large preparative columns is a combined result of many detracting influences. These are summarized and their importance is discussed. Particular attention is given to the way in which resolution is lost as column diameter is increased. Simplified theoretical treatments are given to show the variables which must be controlled for optimum performance. In particular the column plate-height contributions are formulated and shown to have altogether different and unusual properties when compared to analytical column characteristics. These results have many practical implications, and on this basis a number of approaches are suggested for improving the performance of large columns.

This publication has 0 references indexed in Scilit: