A role of MAP1B in Reelin-dependent Neuronal Migration
Open Access
- 8 December 2004
- journal article
- research article
- Published by Oxford University Press (OUP) in Cerebral Cortex
- Vol. 15 (8) , 1134-1145
- https://doi.org/10.1093/cercor/bhh213
Abstract
The signaling cascades governing neuronal migration are believed to link extracellular signals to cytoskeletal components. MAP1B is a neuron-specific microtubule-associated protein implicated in the control of the dynamic stability of microtubules and in the cross-talk between microtubules and actin filaments. Here we show that Reelin can induce mode I MAP1B phosphorylation, both in vivo and in vitro, through gsk3 and cdk5 activation. Additionally, mDab1 participates in the signaling cascade responsible for mode I MAP1B phosphorylation. Conversely, MAP1B-deficient mice display an abnormal structuring of the nervous system, especially in brain laminated areas, indicating a failure in neuronal migration. Therefore, we propose that Reelin can induce post-translational modifications on MAP1B that could correlate with its function in neuronal migration.Keywords
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