Muscle Coenzyme Q10 Level in Statin-Related Myopathy
Open Access
- 1 November 2005
- journal article
- clinical trial
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 62 (11) , 1709-1712
- https://doi.org/10.1001/archneur.62.11.1709
Abstract
Statin drugs (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are widely prescribed drugs that reduce blood cholesterol levels by inhibiting the synthesis of mevalonate, a critical intermediary in the cholesterol pathway. Statin drug therapy has been associated with a variety of muscle complaints, ranging from myalgia and cramps to exercise intolerance, weakness, and, occasionally, acute muscle breakdown with myoglobinuria.1,2 Serum creatine kinase (CK) levels are elevated in all of these conditions.2 It is curious that muscle symptoms and high serum CK levels often persist even after statin drug withdrawal.2Keywords
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