IMMUNOLOGICAL REACTIVITY BETWEEN CHIMERIC CATTLE TWINS

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Abstract
The response of chimeric calves to grafts of cotwin skin was examined by direct observation of the fate of the graft and by collection of lymph from the lymph node which drained the grafted area. Grafts of body skin exchanged between 16 pairs of twins survived for longer periods than did grafts transferred between unrelated calves; all of the former were rejected after 10 wk. Secondary grafts of cotwin body skin were rejected significantly faster. Grafts of auricular skin exchanged between cotwins survived indefinitely in some instances despite the rejection of simultaneously transferred body skin. The magnitude of the blast cell respone observed in efferent lymph in the case of grafts exchanged between cotwins was generally intermediate between that observed in responses to allografts and control autographs. An early peak of blast cell response which occurred some 50 h after placement of allogeneic grafts was not observed in response to cotwin grafts.

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