Thermogenic response to glucagon in cold-acclimated mice.

Publisher Website
Google Scholar
Abstract
Heat production after injection of glucagon and norepinephrine was measured in warm- and cold-acclimated mice. Glucagon and norepinephrine in a dose of 100 .mu.g/100 g caused a marked increase in O2 consumption. Heat production after administration of glucagon and norepinephrine was significantly potentiated by cold acclimation. A significant positive correlation was observed between the increase in O2 consumption after injection of glucagon or norepinephrine and the weight of brown adipose tissue in warm- and cold-acclimated mice. Glucagon is a calorigenic hormone in mice and its effect is potentiated by cold acclimation possibly due to an activation of thermogenic mechanism(s) in brown adipose tissue.