TREVERSAL OF ADRENAL-REGENERATION HYPERTENSION BY AMPHENONE

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Abstract
Rats were operated by unilateral nephrectomy, unilateral adrenalectomy and contralateral adrenal enucleation, they were then given saline to drink. During the process of adrenal regeneration a marked hypertension developed with cardiac and renal hypertrophy. Treatment of adrenal-regeneration hypertensive rats with Amphenone caused a reversal of blood pressure to normotensive limits and decreased the cardiac and renal hypertrophy. Amphenone treatment of rats started two weeks after adrenal-enucleation prevented the anticipated rise in blood pressure. These favourable effects on the blood pressure are accompanied by marked lipid accumulation in the regenerated adrenal gland affecting primarily the fasciculata zone. The administration of Amphenone to normal animals caused no depression in the blood pressure, nor did it affect the hypertension, cardiac hypertrophy, glomerular or arteriolar lesions of adrenalectomized rats given desoxycorticosterone acetate and saline.