In-Vitro and in Vivo Evaluation of Certain Non Steroidal Miti-Inflammatory Drugs in Ophthalmic Myorogel Forms

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Abstract
Monophenylbutazone and flufenamic acid are two non steroidal anti-infalmmatory drugs. They were formulated in carbopol 940 hydrogel. The effect of drug concentration and ageing on the in vitro release characteristics was studied. The release profile agreed with the partition controlled mechanism. Increasing drug concentration accompanied by a decrease in the release rate. Ageing affected the release rate to varing degrees depending on the incorporated drug and its concentration. The prepared hydrogels were evaluated for their healing activities on induced corneal ulcers on rabbit's eye. The tested preparations brought about a significant healing effect on the induced ulcers. The healing activity of the monophenylbutazone gel preparations was found to be higher than that in case of the flufenamic acid