THYROXIN AND TISSUE METABOLISM

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Abstract
Blood drawn by cardiac puncture from American alligators (Alligator mississippiensis), 16 in all, was incubated at 30[degree]C for 24 hrs. Analyses for CO2, O2, glucose and lactic acid were made at the beginning and at the end of the metabolic period. Gas analysis was made by the Haldane method, blood gases by the Van Slyke manometric method. Thyroxin in vivo accelerated the gaseous metabolism, glycolysis and lactic acid production of the blood and lowered the RQ. An initial acidosis was followed by an alkalosis after several mos., as the buffering power of the blood rose. Thyroxin was only slowly destroyed, increased metabolism of the blood being observed after 8-10 mos. In vitro it increased O consumption but not the production of CO2 during the incubation period.

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