Sp1 can displace GHF-1 from its distal binding site and stimulate transcription from the growth hormone gene promoter.
Open Access
- 1 April 1990
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 10 (4) , 1811-1814
- https://doi.org/10.1128/mcb.10.4.1811
Abstract
DNase I footprinting experiments showed that binding activities of Sp1 and of GHF-1 to its distal site on the human growth hormone gene promoter are mutually exclusive. The kinetics of GHF-1 binding were indicative of positive cooperativity. The Sp1 site did not affect promoter activity in cell-free transcription. Still, Sp1 could compensate partially for the decreased stimulation of transcription seen at low GHF-1 concentrations.This publication has 12 references indexed in Scilit:
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