Organizing Axes in Time and Space; 25 Years of Colinear Tinkering
Top Cited Papers
- 18 July 2003
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 301 (5631) , 331-333
- https://doi.org/10.1126/science.1085753
Abstract
During vertebrate development, clustered genes from the Hox family of transcription factors are activated in a precise temporal and spatial sequence that follows their chromosomal order (the “ Hox clock”). Recent advances in the knowledge of the underlying mechanisms reveal that the embryo uses a variety of strategies to implement this colinear process, depending on both the type and the evolutionary history of axial structures. The search for a universal mechanism has likely hampered our understanding of this enigmatic phenomenon, which may be caused by various and unrelated regulatory processes, as long as the final distribution of proteins (the HOX code) is preserved.Keywords
This publication has 35 references indexed in Scilit:
- The Segmentation Clock: Converting Embryonic Time into Spatial PatternScience, 2003
- Serial deletions and duplications suggest a mechanism for the collinearity of Hoxd genes in limbsNature, 2002
- The Drosophila Hox Gene Deformed Sculpts Head Morphology via Direct Regulation of the Apoptosis Activator reaperCell, 2002
- Assigning the Positional Identity of Spinal Motor NeuronsNeuron, 2001
- Elements both 5′ and 3′ to the murine Hoxd4 gene establish anterior borders of expression in mesoderm and neurectodermMechanisms of Development, 1997
- A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1Nature, 1994
- Homeotic genes of the bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-lessCell, 1992
- Homeobox genes and axial patterningPublished by Elsevier ,1992
- Patterning in the vertebrate limbCurrent Opinion in Genetics & Development, 1991
- A gene complex controlling segmentation in DrosophilaNature, 1978