Continuous levodopa infusions to treat complex dystonia in Parkinson's disease
- 1 July 1989
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 39 (7) , 888
- https://doi.org/10.1212/wnl.39.7.888
Abstract
We report the clinical spectrum of 3 patients with Parkinson''s disease who experienced complex patterns of levodopa-related dystonia. Dystonia was unrelieved by multiple medication regimens but responded well to continuous, duodenal levodopa infusions. Patients were able to remain mobile without severe dystonia despite a very narrow window of benefit between the levodopa concentration necessary to achieve the "on" state and that which caused the onset of dystonic spasms.This publication has 7 references indexed in Scilit:
- Motor fluctuations in Parkinson's disease: Central pathophysiological mechanisms, Part IAnnals of Neurology, 1988
- Motor fluctuations in Parkinson's disease: Central pathophysiological mechanisms, part IIAnnals of Neurology, 1988
- Long-term duodenal infusion of levodopa for motor fluctuations in parkinsonismAnnals of Neurology, 1988
- Dystonia in parkinson's disease: Clinical and pharmacological featuresAnnals of Neurology, 1988
- Duodenal delivery of levodopa for on‐off fluctuations in parkinsonism: Preliminary observationsAnnals of Neurology, 1986
- Dystonic Foot Response of ParkinsonismArchives of Neurology, 1980
- Early-Morning DystoniaArchives of Neurology, 1979