Further studies on the use of 2,2,2‐trichloroethyl groups for phosphate protection in phosphoserine peptide synthesis
- 12 January 1992
- journal article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 39 (1) , 82-86
- https://doi.org/10.1111/j.1399-3011.1992.tb01559.x
Abstract
Boc-Ser(PO3Tc2)-OH, Z-Ser(PO3Tc2)-OH and Fmoc-Ser(PO3Tc2)-OH, derivatives useful for peptide synthesis, have been obtained in high yields by acylation of H-Ser(PO3Tc2)-OHCF3COOH. The latter was obtained from Boc- or Z-Ser(PO3Tc2)-OBzl by simultaneous removal of the amino- and carboxy-protecting groups by Pd-catalyzed hydrogenolysis in acetic acid-trifiuoroacetic acid solution. Removal of the Tc-protecting group was efficiently achieved by hydrogenolysis in aqueous ethanol.Keywords
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