Postmenopausal Hormone-Replacement Therapy

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Abstract
Although current epidemiologic evidence overwhelmingly supports the notion that estrogen-replacement therapy protects postmenopausal women against coronary artery disease, the appropriate treatment of these women with gonadal steroids remains controversial. To some extent, this controversy reflects physicians' reluctance to commit patients to decades of treatment with medications whose benefits have only been inferred from observational studies rather than demonstrated in prospective clinical trials. Also, most of the studies have included few details about the type or dose of estrogen or the duration of its use. The paucity of information on the combined use of estrogen and progestin is even more pronounced, . . .