UNIFORM DISTRIBUTION AND CONCENTRATION OF AMINOPEPTIDASE IN PROXIMAL TUBULES OF PIG KIDNEY
Open Access
- 1 August 1973
- journal article
- research article
- Published by SAGE Publications in Journal of Histochemistry & Cytochemistry
- Vol. 21 (8) , 685-692
- https://doi.org/10.1177/21.8.685
Abstract
The concentration of aminopeptidase in cross-sections in proximal tubules of pig kidney was investigated with a specific fluorescent antibody technique and a specific histochemical technique. The concentration was found to be independent of the diameter of the tubule and of the depth of the cortex. Four-micron segments of proximal tubules contained approximately l04 molecules of aminopeptidase/µ2, which is adequate for a rapid hydrolysis of peptides, even in very small concentrations, such as angiotensin II at 10 5 of the physiologic serum concentration. The findings suggest that with regard to this enzyme all sections of the proximal tubule function equivalently.Keywords
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