Genomic organization of the human procollagen α1 (II) collagen gene
- 1 February 1991
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 195 (3) , 593-600
- https://doi.org/10.1111/j.1432-1033.1991.tb15742.x
Abstract
The nucleotide sequence of the human procollagen alpha 1(II) collagen gene extending from within the first intron through exon 15, and part of the 15th intron has been determined. This sequence analysis (7056 bases) identifies the intron/exon organization of the region of this gene encoding the N-propeptide and part of the triple-helical domain. Structural comparison of this with the genes of other human fibrillar collagens shows considerable diversity in terms of size and number of introns and exons that encodes the N-propeptide domain. Although the genomic structure of the human procollagen alpha 1(II) gene is quite different from the rat procollagen alpha 1(II) gene, the nucleotide coding sequences are 89% identical.Keywords
This publication has 27 references indexed in Scilit:
- [57] Sequencing end-labeled DNA with base-specific chemical cleavagesPublished by Elsevier ,2004
- Identification of the Molecular Defect in a Family with Spondyloepiphyseal DysplasiaScience, 1989
- The Stickler syndrome: Evidence for close linkage to the structural gene for type II collagenGenomics, 1987
- Specific-primer-directed DNA sequencingAnalytical Biochemistry, 1986
- Promoter region of the human pro-α1(II)-collagen geneGene, 1986
- Structure of the Type II Collagen GeneAnnals of the New York Academy of Sciences, 1985
- Human proα1(I) collagen gene structure reveals evolutionary conservation of a pattern of introns and exonsNature, 1984
- Isolation and characterization of genomic clones corresponding to the human type II procollagengeneNucleic Acids Research, 1984
- [2] New M13 vectors for cloningPublished by Elsevier ,1983
- Structurally Distinct Collagen TypesAnnual Review of Biochemistry, 1980