Cytotoxic effects of the lipophilic iron chelator omadine
- 18 August 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 204 (2) , 208-212
- https://doi.org/10.1016/0014-5793(86)80813-4
Abstract
Cytotoxic effects were observed following 4 h incubation of human leukaemic cells with the iron chelator 1-hydroxypyridine-2-thione (omadine). Its Cytotoxic activity was comparable to that of the cytotoxic drug doxorubicin. At the same concentration two other effective iron chelators, desferrioxamine and 1,2-dimethyl-3-hydroxypyrid-4-one, were not cytotoxic. Addition of iron augmented the effect of omadine. It is suggested that the lipophilic properties of omadine and of its iron complex cause their intracellular accumulation and potent cytotoxic activity.Keywords
This publication has 19 references indexed in Scilit:
- The study of iron mobilisation from transferrin using α-ketohydroxy heteroaromatic chelatorsBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1986
- Site specificity of iron removal from transferrin by α‐ketohydroxypyridine chelatorsFEBS Letters, 1985
- Antineoplastic and antiherpetic activity of spermidine catecholamide iron chelatorsBiochemical and Biophysical Research Communications, 1984
- Oxidative destruction of DNA by the adriamycin-iron complexBiochemistry, 1984
- A lipophilic iron chelator can replace transferrin as a stimulator of cell proliferation and differentiation.The Journal of cell biology, 1984
- Cytotoxicity Acquired by Conjugation of an Anti‐Thy1.1 Monoclonal Antibody and the Ribosome‐Inactivating Protein, GeloninEuropean Journal of Biochemistry, 1981
- Serum-free cell culture: a unifying approachCell, 1980
- Reduction of RibonucleotidesAnnual Review of Biochemistry, 1979
- Effect of Iron Deficiency and Desferrioxamine on DNA Synthesis in Human CellsBritish Journal of Haematology, 1976
- Toxicology of hydroxypyridinethioneToxicology and Applied Pharmacology, 1960