Two Subtypes of Genotype B (Ba and Bj) of Hepatitis B Virus in Japan
Open Access
- 1 May 2004
- journal article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 38 (9) , 1222-1228
- https://doi.org/10.1086/382885
Abstract
We have previously reported 2 subtypes of hepatitis B virus (HBV) genotype B, one of which has the recombination with genotype C over the precore region plus core gene (Ba) and the other of which does not (Bj). A restriction fragment—length polymorphism method with 2 endonucleases was newly developed for distinguishing between subtypes Ba and Bj and was applied to 313 carriers of HBV genotype B in Japan. Subtype Ba was detected in 38 (12%) and subtype Bj in 275 (88%) of the carriers of HBV genotype B. Hepatitis B e antigen in serum was found more frequently in patients with chronic infection with subtype Ba than in those with chronic infection with subtype Bj (8 [32%] of 25 vs. 25 [9%] of 273; P < .01). The new method for distinguishing between Ba and Bj by restriction fragment—length polymorphism would be useful in examining the distribution of these 2 subtypes in situations in which HBV genotype B is prevalent.Keywords
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