Imaging ex vivo and in vitro brain morphology in animal models with ultrahigh resolution optical coherence tomography

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Abstract
In recent years there has been a constant demand for development of noninvasive or minimally invasive imaging techniques that can be applied in neurosurgery as guiding tools and as an alternative to standard excisional biopsy. So far a vast variety of imaging methods1 2 3 4 ranging from magnetic resonance imaging (MRI) to optical microscopy have been used at different stages in the diagnostics, treatment, and postoperative monitoring of various neuropathologies. Despite all their advantages, each of these methods possesses some inherent limitation related to image resolution, acquisition time, specificity and accuracy of the acquired image or information, etc., which motivates the constant search for new more precise and less invasive imaging modalities.