Expression of the G6PD locus on the human X chromosome is associated with demethylation of three CpG islands within 100 kb of DNA.
Open Access
- 1 February 1988
- journal article
- research article
- Published by Springer Nature in The EMBO Journal
- Vol. 7 (2) , 401-406
- https://doi.org/10.1002/j.1460-2075.1988.tb02827.x
Abstract
We have previously reported that expression of the G6PD locus is correlated with the methylation status of two islands of CpG dinucleotides which are 3′ to the locus and in the 5′ region of two adjacent genes of unknown function, P3 and GdX. We have now examined the methylation of a third CpG island in the promoter region of the G6PD gene itself in DNA from males, females and reactivants that express G6PD on the inactive X chromosome. Our results show that expression of the G6PD gene is associated with concordant demethylation of all three CpG islands in this 100‐kb region of DNA.This publication has 21 references indexed in Scilit:
- CpG-rich islands and the function of DNA methylationNature, 1986
- Differences in methylation on the active and inactive human X chromosomesAnnals of Human Genetics, 1985
- Clusters of CpG dinucleotides implicated by nuclease hypersensitivity as control elements of housekeeping genesNature, 1985
- Differential methylation of hypoxanthine phosphoribosyltransferase genes on active and inactive human X chromosomes.Proceedings of the National Academy of Sciences, 1984
- MAMMALIAN X-CHROMOSOME INACTIVATIONAnnual Review of Genetics, 1983
- Differences in the DNA of the inactive X chromosomes of fetal and extraembryonic tissues of miceCell, 1983
- Derepression with decreased expression of the G6PD locus on the inactive X chromosome in normal human cellsCell, 1982
- Transformation with DNA from 5-azacytidine-reactivated X chromosomes.Proceedings of the National Academy of Sciences, 1982
- Studies of X chromosome DNA methylation in normal human cellsNature, 1982
- X‐CHROMOSOME INACTIVATION AND DEVELOPMENTAL PATTERNS IN MAMMALSBiological Reviews, 1972