The Influence of Dietary Protein on the Toxicity of Sulfanilamide

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Abstract
Daily oral adm. of 1 g. per kg. sulfanilamide to rats maintained on diets of 7 and 30% protein respectively resulted in a higher mortality rate in the animals on the low protein diet. Supplementing the low protein diet with cystine had no effect while supplementing with cystine and methionine reduced the mortality rate to the same level as in the high protein group. From 46-54% of the animals in the low protein groups developed anemia; none of the animals in the high protein group suffered anemia. Examination of blood sulfanilamide levels indicated a greater retention of the drug in animals on the low protein diets. Histologic examination of the tissues failed to reveal specific damage attributable to low protein-sulfanilamide treatments.

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