Effects of Acetylsalicylic Acid on Excretion of Endogenous Metabolites By Man.

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Abstract
Studies of the biochemistry of salicylate reported in the literature suggest that acetylsalicylate may affect "active" renal transport. The effect of acetylsalicylic acid on the excretion rates of creatinine, urea, uric acid, amino nitrogen, inorganic phosphate, sodium, potassium and chloride was studied. A group of 25 college and medical students served as experimental subjects. Urine samples were collected at 15-20 minute intervals after hydration with water until the urine flow ranged between 4-20 ml/min. A series of 4 control samples of urine was collected and 0.6 or 1.8 g of aspirin was given by mouth. Urine samples were then collected for four hours. Fifty four experiments with varying doses of aspirin led to the following findings The drug caused a decrease in Na and Cl excretion in every subject except 1. Aminoaciduria was found in every subject following administration of 1.8 g of the drug. Varying degrees of uricosuria resulted from administration of 1.8 g of aspirin while 0.6 g caused varying retention of uric acid in all subjects. It was suggested that the observed sodium retention was an "adrenal steroid effect" probably related to decreased conjugation of steroid in the liver. The paradoxical effect on uric acid excretion along with the finding of aminoaciduria suggests interference by acetylsalicylate with the energy cycle in the renal tubule cell.

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