Comparative Effects of Adrenaline and Felypressin (Oetapressin) on Consecutive Sections of the Vascular Bed in Canine Adipose Tissue

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Abstract
Blood flow and tissue volume were recorded in the isolated canine s.c. adipose tissue, enclosed in a plethysmograph. Adrenaline [epinephrine] and felypressin (octapressin) were infused intra-arterially at doses producing a blood flow reduction of approximately 60%. Adrenaline (4.6-23 ng/min) caused an initial reduction in tissue volume, indicating a constriction of capacitance vessels. Octapressin (0.46-9.2 ng/min) had no effect on tissue volume. Neither adrenaline or octapressin caused appreciable filtration or absorption, suggesting that the pre- to postcapillary resistance ratio remained unchanged. In contrast to sympathetic stimulation and noradrenaline [norepinephrine], adrenaline significantly reduced the capillary filtration coefficient (CFC) by 34%, the change in CFC being related to the flow reductions, while octapressin did not reduce CFC significantly. The constrictor effect of adrenaline on precapillary sphincter sections and on capacitance vessels is probably greater than that of octapressin in doses producing similar flow reductions.