Twenty skunks were infected with L. pomona. Overt signs of leptospirosis were not apparent The only signs ol infection were mild elevation in temperature and slight to moderate proteinuria. No significant amounts of urinary antibodies were found during the first 2 mo. Later, urinary antibody titers of 2 to 100 were observed. Leptospiruria was found up to 197 days post-inoculation, the end of the observation period. The outcome of the carrier state of leptospiral infection in animals is probably dependent on a qualitative suitability of the infected animal and the susceptibility and defense mechanisms of the host. Soon after the infection is established, the epithelium of the renal convoluted tubules in skunks apparently becomes resistant to reinvasion by the leptospires living in the lumen. Because no further lesions develop in the tubules, the leptospires can survive and grow undisturbed. The activity of urinary antibodies is discussed,.