A FORMAL TOTAL SYNTHESIS OF POLYOXIN J USING 4-O-BENZYL-2,3-O-ISOPROPYLIDENE-l-THREOSE AS A COMMON CHIRAL BUILDING BLOCK
- 5 March 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 13 (3) , 405-408
- https://doi.org/10.1246/cl.1984.405
Abstract
A convergent formal total synthesis of Polyoxin J was achieved. Two fragments, deoxypolyoxin C and 5-O-carbamoylpolyoxamic acid, were synthesized in a highly stereoselective manner from the common chiral building block, 4-O-benzyl-2,3-O-isopropylidene-L-threose, finishing the formal synthesis of Polyoxin J.Keywords
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