Demonstration of a Proteolytic Enzyme, Salivain, in Rat Saliva.

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Abstract
An alkaline proteolytic enzyme was shown to be excreted into the submandibular saliva of the rat and the same enzyme was identified in the mouth and cardial stomach by using immunoelectro-phoresis. The enzyme is similar to salivain, a proteolytic enzyme purifed from rat submandibular gland, in regard to pH optimum, modifier characteristics, molecular weight, mobility in starch gel electrophoresis and substrate specificity. It also precipitates the anti-salivain serum. After stimulation by intraperitoneal injections of isoprenaline the enzyme was found to be excreted into saliva at a concentration of about ten times that found in gland tissue homogenate.

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