Effect of nonsteroid anti-inflammatory drugs on subarachnoid hemorrhage in dogs

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Abstract
The effects of 2 long-acting anti-inflammatory agents on behavioral changes and cerebral vasospasm were evaluated in a canine model of chronic subarachnoid hemorrhage (SAH). The agent with the longest half-life, sudoxicam, clearly reduced both the incidence and the magnitude of the vasospasm, and prevented the usual behavior changes caused by the simulated SAH. Naproxen produced better results than the administration of saline. Prostaglandins and thromboxane may play a role in the pathogenesis of SAH and nonsteroid anti-inflammatory agents exert pharmacological effects by reducing an excessive synthesis of these lipids. Some of these agents may afford an alternative treatment for SAH.