1H and 13C NMR studies of the protonation of isomeric methoxysulmazole analogues
- 1 July 1990
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Chemistry
- Vol. 28 (7) , 573-575
- https://doi.org/10.1002/mrc.1260280703
Abstract
The major protonation sites of six cardiotonic isomeric 2‐aryl‐n‐methoxy‐1H‐imidazo[4,5‐b]‐ and ‐[4,5‐c]‐pyridines (n = 4–7) were determined by 1H and 13C NMR methods. All the 1H‐imidazo[4,5‐c]pyridines and the 7‐methoxy derivative of sulmazole were found to protonate at the pyridyl nitrogen. Protonation occurred at the imidazo nitrogen, however, for the 5‐ and 6‐methoxy derivatives of sulmazole.Keywords
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